Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women
Tai-Huang Chao; Hsing-Ning Yu; Chi-Chuan Huang; Wen-Sheng Liu; Ko-Hsiu Lu


An elevated annual incidence rate of hip fracture has been reported among elderly Taiwanese. Moreover, bone mineral density

(BMD) is the single most reliable predictor of fragility fractures. We aimed to identify the association between gene sequence variants and hip

BMD in postmenopausal Taiwanese women


We prospectively analyzed data from 163 postmenopausal Taiwanese women to test an association between rs7524102, rs6696981, or

rs6993813 single-nucleotide polymorphisms (SNPs) and hip BMD


Our study showed that rs6993813 (osteoprotegerin gene) and rs6696981 (ZBTB40 gene) SNPs have an opposite association with hip

BMD. For rs6993813 genotypic frequencies, the adjusted odds ratio for hip osteoporosis was 9.53 for individuals with T/T minor allele

homozygotes, compared with that of participants with C/C wild-type homozygotes. Hip BMD also had an association with rs6993813 SNPs,

especially in T/T minor allele homozygotes. For rs6696981 SNPs, hip BMD in G/T heterozygotes and at least one mutated T allele was higher

than that in wild-type G/G homozygotes


The gene sequence variant rs6993813 reduced hip BMD and increased the risk of hip osteoporosis, whereas rs6696981 increased hip

BMD in postmenopausal Taiwanese women. This indicated that the two SNPs may provide some explanation for the high risk of hip fracture in

this population.

Journal of the Chinese Medical Association 2012 Vol: 75