In the present study, we tested for an association between single nucleotide polymorphisms (SNPs) and bone

mineral density (BMD) of the hip and lumbar spine in a Taiwanese population by analyzing 252 healthy persons (nonosteoporosis)

and 193 persons with osteoporosis. we found that age; body mass index; family history; and consumption of

coffee or vitamin D were associated with osteoporosis in our Taiwanese population. Our results also indicated that osteoprotegerin

(OPG) SNP (rs6993813 T®C) and receptor activator of nuclear factor kappa-B ligand (RANKL) SNP (rs9594738 C®T)

were significantly associated with BMD in our Taiwanese population. Additionally, we propose that the mean threshold value

of integration of 7 wild-type SNPs (rs7524102 and rs6696981 of 1p36, rs11898505 of 2p16, rs9479055 of 6q25, rs326340

and rs1289759 of 3q13, and rs9594738 of 13q14) can be used for both a Taiwanese reference for bone density testing and to

achieve the effect of grading.