Abstract
An elevated annual incidence rate of hip fracture has been reported among elderly Taiwanese. Moreover, bone mineral density
(BMD) is the single most reliable predictor of fragility fractures. We aimed to identify the association between gene sequence variants and hip
BMD in postmenopausal Taiwanese women
Method
We prospectively analyzed data from 163 postmenopausal Taiwanese women to test an association between rs7524102, rs6696981, or
rs6993813 single-nucleotide polymorphisms (SNPs) and hip BMD
Result
Our study showed that rs6993813 (osteoprotegerin gene) and rs6696981 (ZBTB40 gene) SNPs have an opposite association with hip
BMD. For rs6993813 genotypic frequencies, the adjusted odds ratio for hip osteoporosis was 9.53 for individuals with T/T minor allele
homozygotes, compared with that of participants with C/C wild-type homozygotes. Hip BMD also had an association with rs6993813 SNPs,
especially in T/T minor allele homozygotes. For rs6696981 SNPs, hip BMD in G/T heterozygotes and at least one mutated T allele was higher
than that in wild-type G/G homozygotes
Conclusion
The gene sequence variant rs6993813 reduced hip BMD and increased the risk of hip osteoporosis, whereas rs6696981 increased hip
BMD in postmenopausal Taiwanese women. This indicated that the two SNPs may provide some explanation for the high risk of hip fracture in
this population.
